{"id":671,"date":"2022-10-06T09:49:03","date_gmt":"2022-10-06T09:49:03","guid":{"rendered":"https:\/\/kleomax.com\/?p=671"},"modified":"2022-10-06T09:59:19","modified_gmt":"2022-10-06T09:59:19","slug":"the-potential-use-of-hypochlorous-acid-and-a-smart-prefabricated-sanitising-chamber-to-reduce-occupation-related-covid-19-exposure","status":"publish","type":"post","link":"https:\/\/kleomax.com\/index.php\/2022\/10\/06\/the-potential-use-of-hypochlorous-acid-and-a-smart-prefabricated-sanitising-chamber-to-reduce-occupation-related-covid-19-exposure\/","title":{"rendered":"The Potential Use of Hypochlorous Acid and a Smart Prefabricated Sanitising Chamber to Reduce Occupation-Related COVID-19 Exposure"},"content":{"rendered":"\t\t
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Abstract<\/h2>

This review is extended to cover its viricidal\/bactericidal efficacy in aerosolised or sprayed form which showed an effective dose of as low as 20 ppm and the exposure duration of at least 60 s.<\/span><\/strong> The aerosolised application was also recommended with particle size of less than 200 \u03bcm to increase the contact with pathogens<\/span><\/strong>. The review also includes the safety and toxicity of HOCl with different concentrations. The review calls for more investigations into the effect of HOCl in mist and fog form on the respiratory system when transitioning through the proposed SPSC.<\/p>

Conclusion<\/h2>

In this review on the use of stabilised hypochlorous acid (HOCl) as a potential disinfecting agent for the smart prefabricated sanitising chamber application, the current evidence on the viricidal efficacy, safety, and toxicity are presented. HOCl stabilised at the pH of 3.5\u20135.5 is a weak acid which interacts with structural proteins or viral materials to inactivate micro-organisms. HOCl is currently a disinfectant for SARS-CoV-2 approved by the US Environmental Protection Association under different brands. HOCl with a concentration as low as 20 ppm was found to be effective in disinfecting surfaces including porous rayon. Aerosolised or sprayed HOCl is effective in eliminating micro-strains such as\u00a0Staphylococcus epidermidis<\/em>\u00a0after an exposure of 1 min to 20 mg\/L (equivalent to 20 ppm). The safety and non-toxicity for humans and the environment, the low cost, and the flexibility of applying methods make HOCl an appropriate candidate of disinfectant for indoor settings such as offices, hospitals, and healthcare clinics. Further investigations into the effect of HOCl in mist and fog form on the skin, eyes, and respiratory system especially in special settings such as the proposed smart prefabricated sanitising chamber with presence of organic materials is recommended.<\/p><\/div>

Acknowledgments<\/h2>

The authors would like to acknowledge the financial support from the Australian Research Council (Grant number: IC150100023 and DE290100217).<\/p><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Ref1: The Potential Use of Hypochlorous Acid and a Smart Prefabricated Sanit | RMHP (dovepress.com)<\/a>
Ref2: The Potential Use of Hypochlorous Acid and a Smart Prefabricated Sanitising Chamber to Reduce Occupation-Related COVID-19 Exposure (nih.gov)<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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References<\/h2>
1.\u00a0John Hopkins University\u00a0[homepage on the Internet], US<\/span>. 2020. Available from:\u00a0https:\/\/coronavirus.jhu.edu\/<\/a>. Accessed October1, 2020.<\/span><\/div>
2.\u00a0Vardoulakis S, Sheel M, Lal A, Gray D.\u00a0COVID-19 environmental transmission and preventive public health measures<\/span>.\u00a0Aust N Z J Public Health<\/em><\/span>. 2020;44<\/span>(5<\/span>):ePub. doi:10.1111\/1753-6405.13033\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
3.\u00a0Adekumle A, Meehan M, Rojas-Alvarez D, Trauer J, McBryde E.\u00a0Delaying the COVID\u201019 epidemic in Australia: evaluating the effectiveness of international travel bans<\/span>.\u00a0Aust N Z J Public Health<\/em><\/span>. 2020;44<\/span>(4<\/span>):257\u2013259. doi:10.1111\/1753-6405.13016\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
4.\u00a0World Health Organization [homepage on the Internet]. 2020. July 9\u00a0Transmission of SARS-CoV-2: implications for infection prevention precautions\u201d<\/span>. Available from:\u00a0https:\/\/www.who.int\/<\/a>. Accessed August24, 2020.<\/span><\/div>
5.\u00a0Pascarella G, Strumia A, Piliego C, et al.\u00a0COVID-19 diagnosis and management: a comprehensive review<\/span>.\u00a0J Int Med<\/em><\/span>. 2020;288<\/span>(2<\/span>):192\u2013206. doi:10.1111\/joim.13091\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
6.\u00a0van Doremalen N, Bushmaker T, Morris DH, et al.\u00a0Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1<\/span>.\u00a0N Engl J Med<\/em><\/span>. 2020;382<\/span>:1564\u20131567. doi:10.1056\/NEJMc2004973\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
7.\u00a0Therapeutic goods Administration [homepage on the Internet]. 2020. August 25\u00a0Disinfectants for use against COVID-19 in the ARTG for legal supply in Australia<\/span>. Available from:\u00a0https:\/\/www.tga.gov.au\/disinfectants-use-against-covid-19-artg-legal-supply-australia<\/a>. Accessed August24, 2020<\/span><\/div>
8.\u00a0Chen Y, Chen L, Deng Q, et al.\u00a0The presence of SARS\u2010CoV\u20102 RNA in the feces of COVID\u201019 patients<\/span>.\u00a0J Med Virol<\/em><\/span>. 2020;92<\/span>(7<\/span>):833\u2013840. doi:10.1002\/jmv.25825 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
9.\u00a0Cook TM.\u00a0Personal protective equipment during the coronavirus disease (COVID) 2019 pandemic \u2013 a narrative review<\/span>.\u00a0Anaesth<\/em><\/span>. 2020;75<\/span>(7<\/span>):920\u2013927. doi:10.1111\/anae.15071 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
10.\u00a0Hua W, Zuo Y, Wan R, et al.\u00a0Short-term skin reactions following use of N95 respirators and medical masks<\/span>.\u00a0Contact Dermatitis<\/em><\/span>. 2020;83<\/span>(2<\/span>):115\u2013121. doi:10.1111\/cod.13601\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
11.\u00a0Scarano A, Inchingolo F, Lorusso F.\u00a0Facial skin temperature and discomfort when wearing protective face masks: thermal infrared imaging evaluation and hands moving the mask<\/span>.\u00a0Int J Environ Res Public Health<\/em><\/span>. 2020;17<\/span>(3<\/span>):4624. doi:10.3390\/ijerph17134624\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
12.\u00a0Okamoto K, Rhee Y, Schoeny M, et al.\u00a0Impact of doffing errors on healthcare worker self-contamination when caring for patients on contact precautions<\/span>.\u00a0Infect Control Hosp Epidemiol<\/em><\/span>. 2019;40<\/span>(5<\/span>):559\u2013565. doi:10.1017\/ice.2019.33 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
13.\u00a0Department of Health and Human Services, Victoria State Government [homepage on the Internet]. 2020. August 24 Available from:\u00a0https:\/\/www.dhhs.vic.gov.au\/<\/a>. Accessed August24, 2020.<\/span><\/div>
14.\u00a0Lai J, Cheong K.\u00a0Superposition of COVID-19 waves, anticipating a sustained wave, and lessons for the future<\/span>.\u00a0BioEssays<\/em><\/span>. 2020:2000178.\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
15.\u00a0ABC News [homepage on the Internet]. 2020. August 26 Available from:\u00a0https:\/\/www.abc.net.au\/news\/2020-08-26\/coronavirus-outbreak-at-frankston-hospital-in-melbourne-grows\/12597734<\/a>. Accessed October1, 2020.<\/span><\/div>
16.\u00a0Wickramatillake A, Kurukularatne C.\u00a0SARS-CoV-2 human disinfection chambers: a critical analysis<\/span>.\u00a0Occup Med<\/em><\/span>. 2020;70<\/span>(5<\/span>):330\u2013334. doi:10.1093\/occmed\/kqaa078\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
17.\u00a0Hakim H, Alam MS, Sangsriratanakul N, et al.\u00a0Inactivation of bacteria on surfaces by sprayed slightly acidic hypochlorous acid water: in vitro experiments<\/span>.\u00a0Vet Med Sci<\/em><\/span>. 2016;78<\/span>(7<\/span>):1123\u20131128. doi:10.1292\/jvms.16-0075\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
18.\u00a0United States Environmental Protection Agency [homepage on the Internet], US. 2020. August 20\u00a0List N: disinfectants for Use Against SARS-CoV-2 (COVID-19)<\/span>\u00a0Available from:\u00a0https:\/\/www.epa.gov\/pesticide-registration\/list-n-disinfectants-use-against-sars-cov-2-covid-19<\/a>. Accessed August24, 2020.<\/span><\/div>
19.\u00a0Martin MV, Gallagher MA.\u00a0An investigation of the efficacy of super\u2013oxidised (Optident\/Sterilox) water for the disinfection of dental unit water lines<\/span>.\u00a0BDJ Open<\/em><\/span>. 2005;198<\/span>(6<\/span>):353\u2013354. doi:10.1038\/sj.bdj.4812174 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
20.\u00a0Stroman DW, Mintun K, Epstein AB, et al.\u00a0Reduction in bacterial load using hypochlorous acid hygiene solution on ocular skin<\/span>.\u00a0Clin Ophthalmol<\/em><\/span>. 2017;11<\/span>:707\u2013714. doi:10.2147\/OPTH.S132851\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
21.\u00a0Cap M, Vaudagna S, Mozgovoj M, et al.\u00a0Inactivation of Shiga toxin-producing Escherichia coli in fresh beef by electrolytically-generated hypochlorous acid, peroxyacetic acid, lactic acid and caprylic acid<\/span>.\u00a0Meat Sci<\/em><\/span>. 2019;157<\/span>:107886. doi:10.1016\/j.meatsci.2019.107886 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
22.\u00a0Naka A, Yakubo M, Nakamura K, Kurahashi M.\u00a0Effectiveness of slightly acidic electrolyzed water on bacteria reduction: in vitro and spray evaluation<\/span>.\u00a0Peer J<\/em><\/span>. 2020;8<\/span>:e8593. doi:10.7717\/peerj.8593\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
23.\u00a0Wang L, Bassiri M, Najafi K, et al.\u00a0Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity<\/span>.\u00a0J Burns Wounds<\/em><\/span>. 2007;6<\/span>:e5.\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
24.\u00a0Hao XX, Li BM, Zhang Q, et al.\u00a0Disinfection effectiveness of slightly acidic electrolysed water in swine barns<\/span>.\u00a0J Appl Microbiol<\/em><\/span>. 2013;115<\/span>(3<\/span>):703\u2013710. doi:10.1111\/jam.12274 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
25.\u00a0Block MS, Rowan BG.\u00a0Hypochlorous acid: a review<\/span>.\u00a0J Oral Maxillofac Surg Med Pathol<\/em><\/span>. 2020;78<\/span>(9<\/span>):1461\u20131466.\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
26.\u00a0Overholt B, Reynolds K, Wheeler D, Safer A.\u00a0More effective method for cleaning and disinfecting GI endoscopic procedure rooms<\/span>.\u00a0Open Forum Infect Dis<\/em><\/span>. 2018;5<\/span>(1<\/span>):s346. doi:10.1093\/ofid\/ofy210.984 [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
27.\u00a0Galvin S, Boyle M, Russell R, et al.\u00a0Evaluation of vaporised hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study<\/span>.\u00a0J Hosp Infect<\/em><\/span>. 2012;80<\/span>:67\u201370. doi:10.1016\/j.jhin.2011.10.013 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
28.\u00a0Sotiriou M, Ferguson SF, Davey M, et al.\u00a0Measurement of particle concentrations in a dental office<\/span>.\u00a0Environ Monit Assess<\/em><\/span>. 2008;137<\/span>(1<\/span>):351\u2013361. doi:10.1007\/s10661-007-9770-7 [PubMed<\/a>] [CrossRef<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
29.\u00a0Rasmussen ED, Williams JF.\u00a0Stabilized hypochlorous acid disinfection for highly vulnerable populations: brio HOCL \u2122 wound disinfection and area decontamination<\/span>.\u00a0Proc IEEE Glob Humanit Technol Conf<\/em><\/span>. 2017.\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
30.\u00a0Del Rosso JQ, Bhatia N.\u00a0Status report on topical hypochlorous acid: clinical relevance of specific formulations, potential modes of action, and study outcomes<\/span>.\u00a0J Clin Aesthet Dermatol<\/em><\/span>. 2018;11<\/span>(11<\/span>):36\u201339.\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
31.\u00a0Block M, Rowan B.\u00a0Hypochlorous acid: a review<\/span>.\u00a0J Oral Maxillofac Surg<\/em><\/span>. 2020;78<\/span>(9<\/span>):1461\u20131466.\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div>
32.\u00a0Scarano A, Inchingolo F, Lorusso F.\u00a0Environmental disinfection of a dental clinic during the Covid-19 pandemic: a narrative insight<\/span>.\u00a0Biomed Res Int<\/em><\/span>. 2020;8896812.\u00a0[PMC free article<\/a>]<\/span>\u00a0[PubMed<\/a>]\u00a0[Google Scholar<\/a>]<\/span><\/span><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Abstract This review is extended to cover its viricidal\/bactericidal efficacy in aerosolised or sprayed form which showed an effective dose of as low as 20 ppm and the exposure duration of at least 60 s. The aerosolised application was also recommended with particle size of less than 200 \u03bcm to increase the contact with pathogens.… Read More »The Potential Use of Hypochlorous Acid and a Smart Prefabricated Sanitising Chamber to Reduce Occupation-Related COVID-19 Exposure<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":672,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","neve_meta_reading_time":"","footnotes":""},"categories":[27,22,25,24,21,20,19],"tags":[],"class_list":["post-671","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-benefits","category-child-care","category-family-care","category-general-knowledge","category-news","category-personal-care","category-sanitization"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/posts\/671","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/comments?post=671"}],"version-history":[{"count":8,"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/posts\/671\/revisions"}],"predecessor-version":[{"id":685,"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/posts\/671\/revisions\/685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/media\/672"}],"wp:attachment":[{"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/media?parent=671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/categories?post=671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kleomax.com\/index.php\/wp-json\/wp\/v2\/tags?post=671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}